(R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester

Base Information

Chemical Name:(R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester
CAS No.:1256944-76-9
Molecular Formula:C₁₇H₁₇F₃O₃
Molecular Weight:326.315
Hs Code.:

Synonyms:(R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester

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Chemical Property of (R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester

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Technology Process of (R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester

There total 4 articles about (R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256944-75-8
(R)-3-(4-bromo-3-trifluoromethyl-phenyl)-cyclopentanone

: 140-88-5,9003-32-1
ethyl acrylate

: 1256944-76-9
(R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester

Guidance literature:: With sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 130 ℃; for 3h;

Reference yield:

: 1256944-74-7
2-[4-bromo-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1256944-76-9
(R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / [Rh((R)-BINAP)(norbornadiene)]BF₄ / 1,4-dioxane; water / 0.08 h / 120 °C / Microwave irradiation

2: sodium acetate / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 130 °C

With sodium acetate; triethylamine; [Rh((R)-BINAP)(norbornadiene)]BF₄; palladium diacetate; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 2: Heck Reaction;

Reference yield:

: C₉H₉BBrF₃O₂

: 1256944-76-9
(R)-3-[4-(3-oxocyclopentyl)-2-(trifluoromethyl)phenyl]acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene

2: triethylamine / [Rh((R)-BINAP)(norbornadiene)]BF₄ / 1,4-dioxane; water / 0.08 h / 120 °C / Microwave irradiation

3: sodium acetate / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 130 °C

With sodium acetate; triethylamine; [Rh((R)-BINAP)(norbornadiene)]BF₄; palladium diacetate; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 3: Heck Reaction;