1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene

Base Information

• Chemical Name: 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene
• CAS No.: 181226-73-3
• Molecular Formula: C₂₃H₂₁BrN₂O
• Molecular Weight: 421.337
• Mol file: 181226-73-3.mol

Synonyms:1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene

Chemical Property of 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene

There total 4 articles about 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-[2-(4-Bromo-phenyl)-2-oxo-ethyl]-3-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-1-ium; bromide → 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene (181226-73-3)

Guidance literature:

With sodium hydroxide; for 1h; Heating;

DOI:10.1016/0040-4020(96)00515-7

Reference yield:

O-methylcaprolactim (2525-16-8) → 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene (181226-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / 48 h / 20 °C

2: 80 percent / propan-2-ol / 1 h / Heating

3: 87 percent / sodium hydroxide / H₂O / 1 h / Heating

With sodium hydroxide; In water; isopropyl alcohol; 1: Condensation / 2: Alkylation / 3: Cyclization;

DOI:10.1007/bf01176968

Reference yield:

2-amino-4'-methoxyacetophenone hydrochloride (3883-94-1) → 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene (181226-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / 48 h / 20 °C

2: 80 percent / propan-2-ol / 1 h / Heating

3: 87 percent / sodium hydroxide / H₂O / 1 h / Heating

With sodium hydroxide; In water; isopropyl alcohol; 1: Condensation / 2: Alkylation / 3: Cyclization;

DOI:10.1007/bf01176968

upstream raw materials:

O-methylcaprolactim

2-amino-4'-methoxyacetophenone hydrochloride

3-(4'-anisyl)-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepine