N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate

Base Information

Chemical Name:N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate
CAS No.:1431959-58-8
Molecular Formula:C₂HF₃O₂*C₂₁H₂₀N₆O₃S
Molecular Weight:550.518
Hs Code.:

Synonyms:N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate

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Chemical Property of N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate

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Technology Process of N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate

There total 6 articles about N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431959-92-0
C₉H₇N₃S

: 1431960-78-9
C₁₂H₁₃N₃O₃

: 76-05-1
trifluoroacetic acid

: 1431959-58-8
N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate

Guidance literature:: C₉H₇N₃S; C₁₂H₁₃N₃O₃; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431959-58-8
N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dmap / methanol / 0.5 h / 20 °C / Cooling with ice

1.2: 1.58 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 0.5 h / 20 °C

With dmap; triethylamine; In methanol; dichloromethane;

Reference yield:

: 35283-08-0
ethyl 3-(4-nitrophenyl)prop-2-ynoate

: 1431959-58-8
N-(3-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)propyl)-3-(4-nitrophenyl)propiolamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 16 h / 20 °C

1.2: pH 4

2.1: triethylamine; HATU / tetrahydrofuran / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C

With lithium hydroxide monohydrate; triethylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;