Technology Process of 2-((4R,6R)-2,2-dimethyl-6-((E)-styryl)-1,3-dioxan-4-yl)acetaldehyde
There total 7 articles about 2-((4R,6R)-2,2-dimethyl-6-((E)-styryl)-1,3-dioxan-4-yl)acetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2-iodoxybenzoic acid;
In
dichloromethane; dimethyl sulfoxide;
at 0 - 20 ℃;
for 4h;
DOI:10.1016/j.tetlet.2010.12.070
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
2: 2-iodoxybenzoic acid / dichloromethane; dimethyl sulfoxide / 4 h / 0 - 20 °C
With
2-iodoxybenzoic acid; diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2010.12.070
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol / tetrahydrofuran / -78 - 20 °C / Molecular sieve; Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: acetic acid; tetramethylammonium triacetoxyborohydride / acetonitrile / 5 h / -40 °C
3.1: camphor-10-sulfonic acid / dichloromethane / 2 h / 0 - 20 °C
4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
5.1: 2-iodoxybenzoic acid / dichloromethane; dimethyl sulfoxide / 4 h / 0 - 20 °C
With
titanium(IV) isopropylate; 2-iodoxybenzoic acid; camphor-10-sulfonic acid; (R)-1,1'-Bi-2-naphthol; diisobutylaluminium hydride; acetic acid; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;
1.1: Mukaiyama reaction;
DOI:10.1016/j.tetlet.2010.12.070
