Technology Process of (E)-4-((4S,6R)-2,2-dimethyl-6-((E)-styryl)-1,3-dioxan-4-yl)but-2-enal
There total 12 articles about (E)-4-((4S,6R)-2,2-dimethyl-6-((E)-styryl)-1,3-dioxan-4-yl)but-2-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trans-Crotonaldehyde; (4S,6R)-4-allyl-2,2-dimethyl-6-[(E)-2-phenylvinyl]-1,3-dioxane;
In
toluene;
for 0.25h;
Inert atmosphere;
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
toluene;
for 4h;
Reflux;
Inert atmosphere;
DOI:10.1055/s-0037-1609657
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol / tetrahydrofuran / -78 - 20 °C / Molecular sieve; Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: acetic acid; tetramethylammonium triacetoxyborohydride / acetonitrile / 5 h / -40 °C
3.1: camphor-10-sulfonic acid / dichloromethane / 2 h / 0 - 20 °C
4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
5.1: 2-iodoxybenzoic acid / dichloromethane; dimethyl sulfoxide / 4 h / 0 - 20 °C
6.1: dichloromethane / 3 h / 20 °C
7.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C
With
titanium(IV) isopropylate; 2-iodoxybenzoic acid; camphor-10-sulfonic acid; (R)-1,1'-Bi-2-naphthol; diisobutylaluminium hydride; acetic acid; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;
1.1: Mukaiyama reaction / 6.1: Wittig reaction;
DOI:10.1016/j.tetlet.2010.12.070
