3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester

Base Information

Chemical Name:3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester
CAS No.:152615-30-0
Molecular Formula:C₂₉H₃₈N₂O₆S
Molecular Weight:542.697
Hs Code.:

Synonyms:3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester

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Chemical Property of 3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester

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Technology Process of 3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester

There total 12 articles about 3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 108-24-7
acetic anhydride

: 120787-06-6
3-(S)-mercapto-6-methyl-4-(S)-[({1-(S)-[(methylamino)carbonyl]-2-(4-methoxyphenyl)ethyl}amino)carbonyl]heptanoic acid benzyl ester

: 152615-30-0
3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; In chloroform; for 72h; Ambient temperature;
DOI:10.1021/jm00077a006

Reference yield:

: 120699-30-1
2-(2-methylpropyl)-pent-2-enedicarboxylic acid anhydride

: 152615-30-0
3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 41 percent / 2 h / Heating

2: 69 percent / 1,1'-carbonyldiimidazole / acetonitrile / 0 - 20 °C

3: 25 percent / 456 h / Ambient temperature

4: 33 percent / 35percent aq. NH₃ / methanol / 3 h / Ambient temperature

5: 65 percent / N-methylmorpholine / CHCl₃ / 72 h / Ambient temperature

With 4-methyl-morpholine; ammonium hydroxide; 1,1'-carbonyldiimidazole; In methanol; chloroform; acetonitrile;
DOI:10.1021/jm00077a006

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 152615-30-0
3-(S)-acetylthio-6-methyl-4-(S)-<<<1-(S)-<(methylamino)carbonyl>-2-(4-methoxyphenyl)ethyl>amino>carbonyl>heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) magnesium ethoxide / 1.) EtOH, reflux, 90 min, 2.) EtOH, reflux, 16 h

2: 100 percent / NaBH₄ / ethanol / 2 h / 5 - 10 °C

3: 1.) P₂O₅, 2.) KOH, 3.) Ac₂O

4: 41 percent / 2 h / Heating

5: 69 percent / 1,1'-carbonyldiimidazole / acetonitrile / 0 - 20 °C

6: 25 percent / 456 h / Ambient temperature

7: 33 percent / 35percent aq. NH₃ / methanol / 3 h / Ambient temperature

8: 65 percent / N-methylmorpholine / CHCl₃ / 72 h / Ambient temperature

With 4-methyl-morpholine; potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; magnesium ethylate; acetic anhydride; 1,1'-carbonyldiimidazole; In methanol; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00077a006