Benzoesaeure-cis-4-cyanocyclohexylester

Base Information

• Chemical Name: Benzoesaeure-cis-4-cyanocyclohexylester
• CAS No.: 77407-28-4
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.279
• Mol file: 77407-28-4.mol

Synonyms:Benzoesaeure-cis-4-cyanocyclohexylester

Chemical Property of Benzoesaeure-cis-4-cyanocyclohexylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Benzoesaeure-cis-4-cyanocyclohexylester

There total 2 articles about Benzoesaeure-cis-4-cyanocyclohexylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-hydroxycyclohexane-1-carbonitrile (24056-34-6) + benzoyl chloride (98-88-4) → Benzoesaeure-trans-4-cyanocyclohexylester (77407-29-5) + Benzoesaeure-cis-4-cyanocyclohexylester (77407-28-4)

Guidance literature:

With dmap; In dichloromethane;

Reference yield:

4-hydroxycyclohexanone (13482-22-9) → Benzoesaeure-cis-4-cyanocyclohexylester (77407-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) t-BuOK / 1.) dimethoxyethane, t-butanol; 2.) 6h, RT

2: 37 percent / 4-dimethylaminopyridine / CH₂Cl₂

With dmap; potassium tert-butylate; In dichloromethane;

Reference yield: 74.0%

Benzoesaeure-cis-4-cyanocyclohexylester (77407-28-4) → benzoic acid 4-carbamoyl-cyclohexyl ester

Guidance literature:

With nitrile hydratase from Rhodococcus equi A₄; In methanol; phosphate buffer; at 30 ℃; for 48h; pH=7.5;

DOI:10.1139/v01-205

upstream raw materials:

4-hydroxycyclohexane-1-carbonitrile

benzoyl chloride

4-hydroxycyclohexanone

Downstream raw materials:

benzoic acid methyl ester

cis-4-Cyanocyclohexanol