Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

Base Information

Chemical Name:Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester
CAS No.:225113-27-9
Molecular Formula:C₃₅H₆₁NO₉SSi₂
Molecular Weight:728.108
Hs Code.:

Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

Synonyms:Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

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Chemical Property of Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

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Technology Process of Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

There total 7 articles about Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134436-16-1
di-t-butylchlorosilane monotriflate

: 225113-27-9
Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, -23 deg C, 2.) THF, from -78 deg C to -25 deg C

2: 85 percent Spectr_. / CHCl₃; acetonitrile / 8 h / Ambient temperature

3: methylaluminum bis(2,6-diphenylphenoxide) / CH₂Cl₂ / 2 h / -50 °C

4: NaHCO₃ / benzene / 4 h / Heating

5: 86 percent / K₂OsO₂(OH)4, aq. K₂CO₃, NaHCO₃, K₃Fe(CN)6, (DHQD)2-AQN ligand / 2-methyl-propan-2-ol / Ambient temperature

6: 93 percent / pyridine / 4 h / Ambient temperature

7: pyridine / 0.5 h / Ambient temperature

With pyridine; n-butyllithium; (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; methylaluminium bis(2,6-diphenylphenoxide); potassium hexacyanoferrate(III); In dichloromethane; chloroform; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja9829970

Reference yield:

: 225113-08-6
[((Z)-Buta-1,3-dienyl)oxy]-di-tert-butyl-chloro-silane

: 225113-27-9
Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent Spectr_. / CHCl₃; acetonitrile / 8 h / Ambient temperature

2: methylaluminum bis(2,6-diphenylphenoxide) / CH₂Cl₂ / 2 h / -50 °C

3: NaHCO₃ / benzene / 4 h / Heating

4: 86 percent / K₂OsO₂(OH)4, aq. K₂CO₃, NaHCO₃, K₃Fe(CN)6, (DHQD)2-AQN ligand / 2-methyl-propan-2-ol / Ambient temperature

5: 93 percent / pyridine / 4 h / Ambient temperature

6: pyridine / 0.5 h / Ambient temperature

With pyridine; (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; methylaluminium bis(2,6-diphenylphenoxide); potassium hexacyanoferrate(III); In dichloromethane; chloroform; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja9829970

Reference yield:

: 225113-07-5
[((Z)-Buta-1,3-dienyl)oxy]-di-tert-butyl-((E)-2-nitro-vinyloxy)-silane

: 225113-27-9
Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2S,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: methylaluminum bis(2,6-diphenylphenoxide) / CH₂Cl₂ / 2 h / -50 °C

2: NaHCO₃ / benzene / 4 h / Heating

3: 86 percent / K₂OsO₂(OH)4, aq. K₂CO₃, NaHCO₃, K₃Fe(CN)6, (DHQD)2-AQN ligand / 2-methyl-propan-2-ol / Ambient temperature

4: 93 percent / pyridine / 4 h / Ambient temperature

5: pyridine / 0.5 h / Ambient temperature

With pyridine; (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; methylaluminium bis(2,6-diphenylphenoxide); potassium hexacyanoferrate(III); In dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1021/ja9829970