(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

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Chemical Name:(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol
CAS No.:225113-30-4
Molecular Formula:C₃₄H₅₉NO₇Si₂
Molecular Weight:650.016
Hs Code.:

(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

Synonyms:(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

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Chemical Property of (S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

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Technology Process of (S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

There total 6 articles about (S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 225113-12-2
(S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

: 225113-30-4
(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

Guidance literature:: With pyridine; for 4h; Ambient temperature;
DOI:10.1021/ja9829970

Reference yield:

: 134436-16-1
di-t-butylchlorosilane monotriflate

: 225113-30-4
(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, -23 deg C, 2.) THF, from -78 deg C to -25 deg C

2: 85 percent Spectr_. / CHCl₃; acetonitrile / 8 h / Ambient temperature

3: methylaluminum bis(2,6-diphenylphenoxide) / CH₂Cl₂ / 2 h / -50 °C

4: NaHCO₃ / benzene / 4 h / Heating

5: 86 percent / K₂OsO₂(OH)4, aq. K₂CO₃, NaHCO₃, K₃Fe(CN)6, (DHQD)2-AQN ligand / 2-methyl-propan-2-ol / Ambient temperature

6: 93 percent / pyridine / 4 h / Ambient temperature

With pyridine; n-butyllithium; (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; methylaluminium bis(2,6-diphenylphenoxide); potassium hexacyanoferrate(III); In dichloromethane; chloroform; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja9829970

Reference yield:

: 225113-08-6
[((Z)-Buta-1,3-dienyl)oxy]-di-tert-butyl-chloro-silane

: 225113-30-4
(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,2aR,5aS,7R,8bR)-4,4-di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent Spectr_. / CHCl₃; acetonitrile / 8 h / Ambient temperature

2: methylaluminum bis(2,6-diphenylphenoxide) / CH₂Cl₂ / 2 h / -50 °C

3: NaHCO₃ / benzene / 4 h / Heating

4: 86 percent / K₂OsO₂(OH)4, aq. K₂CO₃, NaHCO₃, K₃Fe(CN)6, (DHQD)2-AQN ligand / 2-methyl-propan-2-ol / Ambient temperature

5: 93 percent / pyridine / 4 h / Ambient temperature

With pyridine; (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; methylaluminium bis(2,6-diphenylphenoxide); potassium hexacyanoferrate(III); In dichloromethane; chloroform; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja9829970