ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

Base Information

• Chemical Name: ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate
• CAS No.: 1384513-05-6
• Molecular Formula: C₂₀H₁₈ClIO₄
• Molecular Weight: 484.718
• Mol file: 1384513-05-6.mol

Synonyms:ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

Chemical Property of ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

There total 3 articles about ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-iodobenzaldehyde (696-41-3) → ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate (1384513-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; acetic acid / toluene / Inert atmosphere; Reflux

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere

With piperidine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; In toluene;

DOI:10.1021/jm300608w

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate (1384513-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; acetic acid / toluene / Inert atmosphere; Reflux

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere

With piperidine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; In toluene;

DOI:10.1021/jm300608w

Reference yield:

ethyl 2-(3-iodobenzylidene)-3-oxobutanoate + 4-chlorobenzaldehyde (104-88-1) → ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate (1384513-05-6)

Guidance literature:

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; at 70 ℃; Inert atmosphere;

DOI:10.1021/jm300608w

upstream raw materials:

4-chlorobenzaldehyde

m-iodobenzaldehyde

ethyl acetoacetate

Downstream raw materials:

ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

ethyl 1-butyl-5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

5-(4-chlorophenyl)-1,2-dimethyl-N-(methylsulfonyl)-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxamide

1-(3-(4-chloro-2-(4-chlorophenyl)-1,5-dimethyl-1H-pyrrol-3-yl)phenyl)-4-(4-nitrophenyl)piperazine