5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

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Chemical Name:5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid
CAS No.:1384513-15-8
Molecular Formula:C₃₀H₂₉ClN₄O₄
Molecular Weight:545.038
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

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Chemical Property of 5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

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Technology Process of 5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

There total 6 articles about 5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 1384513-11-4
5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylic acid

: 1384513-15-8
5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm300608w

Reference yield:

: 696-41-3
m-iodobenzaldehyde

: 1384513-15-8
5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine; acetic acid / toluene / Inert atmosphere; Reflux

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere

3: methanol / Inert atmosphere

4: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere

5: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 80 °C / Inert atmosphere

With piperidine; copper(l) iodide; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; acetic acid; triethylamine; L-proline; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; toluene; 3: Paal-Knorr pyrrole synthesis;
DOI:10.1021/jm300608w

Reference yield:

: 1384513-05-6
ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 1384513-15-8
5-(4-chlorophenyl)-1-ethyl-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / Inert atmosphere

2: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere

3: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 80 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; L-proline; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 1: Paal-Knorr pyrrole synthesis;
DOI:10.1021/jm300608w