phosphinic acid

Base Information

• Chemical Name: phosphinic acid
• CAS No.: 14097-15-5
• Molecular Formula: HO₂P
• Molecular Weight: 63.9805
• Mol file: 14097-15-5.mol

Synonyms:phosphinic acid

Chemical Property of phosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phosphinic acid

There total 3 articles about phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosphan (7803-51-2) + oxygen → phosphorus dioxide (12164-97-5,12037-06-8) + dihydrophosphoryl radical (97516-21-7) + cis-HOPO (14097-15-5) + PO3 radical (12651-01-3) + phosphorus pentoxide

Guidance literature:

Irradiation (UV/VIS); codeposition of Ar/PH3 and Ar/O (atomic O obtained by microwave discharge) at 12 K in Ar-matrix (vacuum), irradiation (1000-W mercury high-pressure arc lamp, 220-1000 nm); further products: HPOH, PO, HPO, HOPO2, H2P(OH), (HO)2HPO, HP(O2)O; IR spectroscopy (before and after irradiation);

DOI:10.1021/j100327a012

Reference yield:

→ phosphinic acid (14097-15-5) + 3-phenyl-2-isoxazolin-5-yl(P-methyl)phosphinic acid (125674-78-4)

Guidance literature:

Reference yield:

→ phosphinic acid (14097-15-5) + 4-[[[1-(4-Fluorophenyl)-3-(1-methylethyl)-1H-indol-2-yl]ethynyl]hydroxyphosphinyl]-3-oxobutanoic acid (156212-56-5)

Guidance literature:

upstream raw materials:

phosphan

Downstream raw materials:

3-(2-pyridinylamino)-phenylboronic acid

2,4-di(benzyloxycarbonyl)butylphosphinic acid

methoxycarbonylmethyl P-methyl[α-(2,4-dichloro-5-nitrophenoxy)ethyl]phosphinate

[(RS)-2-[(benzyloxy)carbonyl]-4-methylpentyl]phosphinic acid

Refernces

Phosphinate selective hosts and importance of C–H hydrogen bonding for affinity modulation toward anion guests

10.1016/j.tetlet.2018.03.066

The research aims to develop selective anion receptors that utilize weak C-H hydrogen bonds, with a focus on phosphinate receptors. Phosphinates are significant in nature due to their association with metabolic diseases and conditions like obesity, NASH, hypercholesterolemia, and diabetes. The researchers designed and synthesized three receptors (1, 2, and 3) that utilize both amide N-H and alpha C-H (Cα-H) to the carbonyl group, differing in the substituent group attached to the alpha carbon, which affects the polarity of the CαH bond and thus the strength of association with anion guests. The study concluded that host 3, with a positively charged pyridinium group, showed the highest binding affinity due to the increased polarity of the Cα-H bond, demonstrating the importance of C-H hydrogen bonding as a modulating element for anionic recognition. Key chemicals used in the synthesis include 1,2-phenylenediamine, acetic acid, cyanoacetic acid, chloroacetyl chloride, pyridine, and various anions for testing, such as dimethyl phosphinate, benzoate, nitrite, and others.