(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Base Information

Chemical Name:(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine
CAS No.:1283098-11-2
Molecular Formula:C₂₃H₂₁NO
Molecular Weight:327.426
Hs Code.:

Synonyms:(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

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Chemical Property of (7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

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Technology Process of (7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

There total 2 articles about (7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1283098-16-7
(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-ethynyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

: 1283098-11-2
(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Guidance literature:: With Lindlar's catalyst; hydrogen; In tetrahydrofuran; at 20 ℃; for 0.166667h; under 760.051 Torr;
DOI:10.1021/jo200069m

Reference yield:

: 667870-41-9
(7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

: 1283098-11-2
(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -40 - 0 °C / Inert atmosphere

2: Lindlar's catalyst; hydrogen / tetrahydrofuran / 0.17 h / 20 °C / 760.05 Torr

With Lindlar's catalyst; hydrogen; In tetrahydrofuran;
DOI:10.1021/jo200069m

Reference yield: 96.0%

: 1283098-11-2
(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

: 1730-25-2
allylmagnesium bromide

: 1042368-71-7
C₂₆H₂₇NO

Guidance literature:: (7aR,10R,12S)-7a,8,9,10-tetrahydro-10-vinyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine; allylmagnesium bromide; In diethyl ether; at -40 ℃; for 1h;

With water; ammonium chloride; In diethyl ether;
DOI:10.1021/jo200069m