N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide

Base Information

Chemical Name:N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide
CAS No.:1620291-96-4
Molecular Formula:C₂₄H₂₁N₅O₄
Molecular Weight:443.462
Hs Code.:

Synonyms:N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide

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Chemical Property of N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide

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Technology Process of N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide

There total 2 articles about N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620294-33-8
tert-butyl ((5-((2-(6-(benzyloxy)pyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

: 139022-25-6
imidazo[1,2-a]pyridine-6-carboxylic acid

: 1620291-95-3
N-((5-((2-(6-(benzyloxy)pyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

: 1620291-96-4
N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide

Guidance literature:: tert-butyl ((5-((2-(6-(benzyloxy)pyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate; With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 12h; Inert atmosphere;

imidazo[1,2-a]pyridine-6-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 832735-54-3
2-(benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1620294-98-5
tert-butyl ((5-((2-bromophenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

: 1620291-95-3
N-((5-((2-(6-(benzyloxy)pyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

: 1620291-96-4
N-((5-((2-(6-hydroxypyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazol[1,2-a]pyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

2.1: hydrogenchloride / diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; diethyl ether; water; 1.1: |Suzuki Coupling;