methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate

Base Information

• Chemical Name: methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate
• CAS No.: 1055969-09-9
• Molecular Formula: C₂₂H₂₅F₃N₂O₅
• Molecular Weight: 454.446

Synonyms:methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate

Chemical Property of methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate

Chemical Property:

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Technology Process of methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate

There total 2 articles about methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H22F3NO5S + methyl 5-hydroxy-3-pyridinecarboxylate (30766-22-4) → methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate (1055969-09-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 18h;

Reference yield:

1,1-dimethylethyl ((1S)-2-hydroxy-1-{[3-(trifluoromethyl)phenyl]methyl}ethyl)carbamate (944470-70-6) + methyl 5-hydroxy-3-pyridinecarboxylate (30766-22-4) → methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate (1055969-09-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 3.16667h;

DOI:10.1016/j.ejmech.2009.12.036

Reference yield:

6,7-dimethoxy-4-methyl-3-cyanoquinoline (1055962-40-7) + methyl 5-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propyl}oxy)nicotinate (1055969-09-9) → C34H33F3N4O6

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 3.5h;

DOI:10.1016/j.ejmech.2009.12.036

upstream raw materials:

methyl 5-hydroxy-3-pyridinecarboxylate

1,1-dimethylethyl ((1S)-2-hydroxy-1-{[3-(trifluoromethyl)phenyl]methyl}ethyl)carbamate

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