Technology Process of sodium 2,2-dimethyl-3-(4-{5-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)propanoate
There total 11 articles about sodium 2,2-dimethyl-3-(4-{5-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
water; acetonitrile;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 3 h / 70 °C
2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 80 °C / Inert atmosphere
3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere
4.1: hydroxylamine / tetrahydrofuran; methanol; water / 4 h / 80 °C
5.1: 2 h / 20 °C
5.2: 2 h / 20 °C / Inert atmosphere
6.1: potassium carbonate / dichloromethane; water / 45 °C
7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C
8.1: sodium hydroxide / water; acetonitrile / 20 °C
With
water; hydroxylamine; potassium acetate; sodium carbonate; potassium carbonate; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 3 h / 70 °C
2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 80 °C / Inert atmosphere
3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere
4.1: hydroxylamine / tetrahydrofuran; methanol; water / 4 h / 80 °C
5.1: 2 h / 20 °C
5.2: 2 h / 20 °C / Inert atmosphere
6.1: potassium carbonate / dichloromethane; water / 45 °C
7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C
8.1: sodium hydroxide / water; acetonitrile / 20 °C
With
water; hydroxylamine; potassium acetate; sodium carbonate; potassium carbonate; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
![2,2-dimethyl-3-(4-{5-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)propanoic acid](/Databaselist/images/loading.webp)
