methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

Base Information

Chemical Name:methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate
CAS No.:1382998-79-9
Molecular Formula:C₂H₄O₂*C₁₈H₂₁N₃O₃
Molecular Weight:387.436
Hs Code.:

Synonyms:methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

Suppliers and Price of methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

There total 8 articles about methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383001-90-8
methyl 3-(4-{5-[amino(hydroxyimino)methyl]pyridin-2-yl}phenoxy)-2,2-dimethylpropanoate

: 108-24-7
acetic anhydride

: 64-19-7,77671-22-8
acetic acid

: 1382998-79-9
methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

Guidance literature:: methyl 3-(4-{5-[amino(hydroxyimino)methyl]pyridin-2-yl}phenoxy)-2,2-dimethylpropanoate; acetic anhydride; acetic acid; at 20 ℃; for 2h;

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: C₁₈H₂₁N₃O₄

: 64-19-7,77671-22-8
acetic acid

: 1382998-79-9
methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

Guidance literature:: C₁₈H₂₁N₃O₄; acetic acid; With acetic anhydride; at 20 ℃; for 1.75h;

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1382998-79-9
methyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}-phenoxy)-2,2-dimethylpropanoate acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 - 80 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

4.1: hydroxylamine / tetrahydrofuran; methanol / 4 h / 80 °C

5.1: acetic anhydride / 1.75 h / 20 °C

5.2: 2 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydroxylamine; potassium acetate; acetic anhydride; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; toluene; 1.1: |Mitsunobu Displacement / 3.1: |Suzuki Coupling;