(S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Name:(S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester
CAS No.:343333-12-0
Molecular Formula:C₄₆H₅₆N₄O₇Si
Molecular Weight:805.059
Hs Code.:

Synonyms:(S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

There total 6 articles about (S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 343333-10-8
(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-acetaldehyde

: 89106-03-6
6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

: 343333-12-0
(S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 12h;
DOI:10.1021/ja005886l

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 343333-12-0
(S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 67 percent / Na / methanol / 5 h / Heating

2.1: 71 percent / POCl₃; N,N-dimethylaniline / Heating

3.1: NaH / tetrahydrofuran / 12 h / Heating

3.2: NaIO₄; OsO₄ / dioxane; H₂O / 12 h / 20 °C

4.1: 55 percent / diisopropylethylamine; NaB(OAc)3H / 1,2-dichloro-ethane / 12 h / 20 °C

With sodium; sodium tris(acetoxy)borohydride; sodium hydride; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1021/ja005886l

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 343333-12-0
(S)-6-Benzyloxycarbonylamino-2-[2-(2,4,6-tris-benzyloxy-pyrimidin-5-yl)-ethylamino]-hexanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: DCC; DMAP / CH₂Cl₂ / 22 h / 20 °C

1.2: 95 percent / TFA / CH₂Cl₂ / 1.5 h / 20 °C

2.1: 55 percent / diisopropylethylamine; NaB(OAc)3H / 1,2-dichloro-ethane / 12 h / 20 °C

With dmap; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ja005886l