(S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester
CAS No.:112888-87-6
Molecular Formula:C₃₀H₃₁F₃N₄O₆
Molecular Weight:600.595
Hs Code.:

Synonyms:(S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

Suppliers and Price of (S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

There total 5 articles about (S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 112888-86-5
(S)-2-(4-Prop-2-ynylamino-2-trifluoromethyl-benzoylamino)-pentanedioic acid diethyl ester

: 112888-43-4
4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

: 112888-87-6
(S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: With magnesium oxide; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1021/jm00173a026

Reference yield:

: 320-37-6
4-nitro-2-(trifluoromethyl)benzoic acid

: 112888-87-6
(S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / toluene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 2 h

3: H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

4: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

5: 64 percent / MgO / dimethylformamide / 18 h / 80 °C

With thionyl chloride; hydrogen; magnesium oxide; potassium carbonate; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a026

Reference yield:

: 98187-15-6
3-trifluoromethyl-4-nitrobenzoyl chloride

: 112888-87-6
(S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-trifluoromethyl-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

3: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

4: 64 percent / MgO / dimethylformamide / 18 h / 80 °C

With hydrogen; magnesium oxide; potassium carbonate; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a026