320-37-6

Basic information

• Product Name: 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID&
• Synonyms: 4-Nitro-2-trifluoromethylbenzo;4-Nitro-2-(trifluoromethyl)benzoic acid,97%;2-TrifluoroMethyl-4-nitrobenzoic acid;2-Carboxy-5-nitrobenzotrifluoride;4-Nitro-2-(trifluoromethyl)benzoic acid 97%
• CAS NO: 320-37-6
• Molecular Formula: C₈H₄F₃NO₄
• Molecular Weight: 235.12
• Product Categories: Benzoic acid;C8;Carbonyl Compounds;Carboxylic Acids;Fluorine series
• Mol File: 320-37-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 138-142 °C(lit.)
• Boiling Point: 321.4 °C at 760 mmHg
• Flash Point: 148.2 °C
• Appearance: White to off-white/Powder
• Density: 1.596 g/cm³
• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.40±0.32(Predicted)
• CAS DataBase Reference: 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID&(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID&(320-37-6)
• EPA Substance Registry System: 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID&(320-37-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 320-37-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C8H4F3NO4/c9-8(10,11)6-3-4(12(15)16)1-2-5(6)7(13)14/h1-3H,(H,13,14)

Upstream product

• 22227-54-9 4-nitro-2-trifluoromethylbenzamide 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 124-38-9 carbon dioxide 
• 367-67-9 2-bromo-5-nitro-benzotrifluoride 
• 1813-24-7 5-methyl-2-nitro-4-triflouromethyl-phenylamine 
• 18018-35-4 1-chloro-5-methyl-2-nitro-4-(trifluoromethyl)benzene 
• 13630-15-4 1-Chlor-3-methyl-4-trichlormethyl-benzol 
• 13630-22-3 4-chloro-2-methyl-1-(trifluoromethyl)benzene 
• 3274-12-2 4-methyl-4-(trichloromethyl)cyclohexa-2,5-dien-1-one 
• 433-97-6 2-trifluoromethylbenzoic acid 
• 89976-12-5 1-methyl-4-nitro-2-(trifluoromethyl) benzene 
• 320-47-8 4-nitro-2-trifluoromethylbenzonitrile 

Downstream Products

• 393-06-6 4-amino-2-(trifluoromethyl)benzoic acid 
• 98187-15-6 3-trifluoromethyl-4-nitrobenzoyl chloride 
• 446305-77-7 3-trifluoromethyl-4-(pyrrolidine-1-yl-carbonyl)-nitrobenzene 
• 859027-06-8 (4-nitro-2-(trifluoromethyl)phenyl)methanol 

Relevant articles and documents

Fluorine-containing aromatic diamine compound and preparation method thereof, and fluorine-containing polyimide compound and preparation method thereof

The invention provides a fluorine-containing aromatic diamine compound and a preparation method thereof, and a fluorine-containing polyimide compound and a preparation method thereof. The fluorine-containing aromatic diamine compound has a structural general formula shown in the specification. The preparation method of the fluorine-containing aromatic diamine compound comprises the following stepsof: mixing materials including a compound A and a compound B, carrying out a first reaction to obtain a compound C, and carrying out a hydrogenation reaction on the compound C to obtain the fluorine-containing aromatic diamine compound. Raw materials of the fluorine-containing polyimide compound comprise the fluorine-containing aromatic diamine compound. The preparation method of the fluorine-containing polyimide compound comprises the following steps of: mixing materials including the fluorine-containing aromatic diamine compound and a dianhydride compound to obtain a mixture, and then carrying out a sixth reaction to obtain a precursor; and carrying out dehydration cyclization reaction on the pre-polymer, and carrying out post-treatment to obtain the fluorine-containing polyimide compound. The polyimide compound prepared from the fluorine-containing aromatic diamine compound provided by the invention is good in solubility, relatively high in transmittance and good in mechanical property.

1H-1,8- NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS

The present invention relates to novel antiproliferative1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition of tyrosine kinases in warm blooded animals. The compounds can overcome imatinib induced drug resistance.

NOVEL CARBOXAMIDES, PRODUCTION AND USE THEREOF AS MEDICAMENTS

The invention relates to novel carboxamides of general formula (I), in which R1 to R5 are as defined in claim 1, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, and the production and use thereof as medicaments. The compounds of the above general formula (I) have useful pharmacological effects, in particular an anti-thrombotic effect and a factor Xa inhibiting effect.