320-37-6

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C8H4F3NO4/c9-8(10,11)6-3-4(12(15)16)1-2-5(6)7(13)14/h1-3H,(H,13,14)

Upstream product

• 320-47-8 4-nitro-2-trifluoromethylbenzonitrile 
• 433-97-6 2-trifluoromethylbenzoic acid 
• 18018-35-4 1-chloro-5-methyl-2-nitro-4-(trifluoromethyl)benzene 
• 22227-54-9 4-nitro-2-trifluoromethylbenzamide 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 124-38-9 carbon dioxide 
• 367-67-9 2-bromo-5-nitro-benzotrifluoride 
• 1813-24-7 5-methyl-2-nitro-4-triflouromethyl-phenylamine 
• 13630-15-4 1-Chlor-3-methyl-4-trichlormethyl-benzol 
• 13630-22-3 4-chloro-2-methyl-1-(trifluoromethyl)benzene 
• 3274-12-2 4-methyl-4-(trichloromethyl)cyclohexa-2,5-dien-1-one 
• 89976-12-5 1-methyl-4-nitro-2-(trifluoromethyl) benzene 

Downstream Products

• 393-06-6 4-amino-2-(trifluoromethyl)benzoic acid 
• 446305-77-7 3-trifluoromethyl-4-(pyrrolidine-1-yl-carbonyl)-nitrobenzene 
• 859027-06-8 (4-nitro-2-(trifluoromethyl)phenyl)methanol 
• 1124214-04-5 3-((4-(4-amino-2-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide 
• 1124214-02-3 N-tert-butyl-3-((4-(4-(3-neopentylureido)-2-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)benzamide 

Relevant academic research and scientific papers

Fluorine-containing aromatic diamine compound and preparation method thereof, and fluorine-containing polyimide compound and preparation method thereof

The invention provides a fluorine-containing aromatic diamine compound and a preparation method thereof, and a fluorine-containing polyimide compound and a preparation method thereof. The fluorine-containing aromatic diamine compound has a structural general formula shown in the specification. The preparation method of the fluorine-containing aromatic diamine compound comprises the following stepsof: mixing materials including a compound A and a compound B, carrying out a first reaction to obtain a compound C, and carrying out a hydrogenation reaction on the compound C to obtain the fluorine-containing aromatic diamine compound. Raw materials of the fluorine-containing polyimide compound comprise the fluorine-containing aromatic diamine compound. The preparation method of the fluorine-containing polyimide compound comprises the following steps of: mixing materials including the fluorine-containing aromatic diamine compound and a dianhydride compound to obtain a mixture, and then carrying out a sixth reaction to obtain a precursor; and carrying out dehydration cyclization reaction on the pre-polymer, and carrying out post-treatment to obtain the fluorine-containing polyimide compound. The polyimide compound prepared from the fluorine-containing aromatic diamine compound provided by the invention is good in solubility, relatively high in transmittance and good in mechanical property.

DIAMINE COMPOUND AND METHOD FOR PRODUCING SAME

The present invention provides a novel diamine compound capable of producing a polymer which exhibits greatly enhanced mechanical properties and heat resistance while maintaining transparency. A film including a polymer produced using the diamine compound has excellent transparency, heat resistance, mechanical strength and flexibility, and thus can be used in various fields, such as in a device substrate, a display cover substrate, an optical film, an Integrated circuit (IC) package, an adhesive film, a multi-layer flexible printed circuit (FPC), a tape, a touch panel and an optical disc protection film, and the like.

1H-1,8- NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS

The present invention relates to novel antiproliferative1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition of tyrosine kinases in warm blooded animals. The compounds can overcome imatinib induced drug resistance.

DIARYL UREA DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES

The invention relates to the use of diaryl urea derivatives for the manufacture of pharmaceutical compositions for the treatment of RET dependent disorders, especially RET dependent tumor diseases. The invention further relates to novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and their use in the treatment of the animal or human body, especially in the treatment of a protein kinase dependent disease, to pharmaceutical compositions comprising such novel N-[4-pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives and to the use of such novel N-[4-(pyrimidin-4-yloxy)-phenyl]-N’-phenyl-urea derivatives for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as tumour diseases.

NOVEL CARBOXAMIDES, PRODUCTION AND USE THEREOF AS MEDICAMENTS

The invention relates to novel carboxamides of general formula (I), in which R1 to R5 are as defined in claim 1, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, and the production and use thereof as medicaments. The compounds of the above general formula (I) have useful pharmacological effects, in particular an anti-thrombotic effect and a factor Xa inhibiting effect.

Anti-tumour agents

A quinazoline of the formula: STR1 wherein R1 is alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, aryl, aryloxy, arylalkyl, halogeno, hydroxy, mercapto, pyridylthio, pyrimidinylthio, or substituted alkyl or alkoxy; wherein R2 is hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl or alkanoyl; wherein Ar is phenylene, naphthylene or heterocyclene which is unsubstituted or bears one or more substituents and wherein R3 is such that R3 --NH2 is an amino acid; or a pharmaceutically-acceptable salt or ester thereof. The compounds possess anti-tumour activity.