(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

Base Information

Chemical Name:(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide
CAS No.:1033766-07-2
Molecular Formula:C₂₃H₂₂FN₅O₆S₂
Molecular Weight:547.588
Hs Code.:

(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

Synonyms:(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

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Chemical Property of (1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

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Technology Process of (1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

There total 11 articles about (1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.4%

: 1000313-20-1
(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid

: 1033766-35-6
(1S,5R)-2-(4-fluoro-benzylamino)-2-aza-bicyclo[3.1.0]hexane-1-carboxylic acid methyl ester

: 1033766-07-2
(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

Guidance literature:: (7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid; (1S,5R)-2-(4-fluoro-benzylamino)-2-aza-bicyclo[3.1.0]hexane-1-carboxylic acid methyl ester; With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃; for 23h;

Reference yield:

: 96-72-0
2-chloro-5-nitrobenzenesulfonamide

: 1033766-07-2
(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia; ammonium carbonate / copper(II) sulfide / water / 4 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 26 h / 25 °C / 760.05 Torr

3.1: pyridine / acetonitrile / 16 h / 25 °C

4.1: diethyl ether; N,N-dimethyl acetamide / 1 h / 25 °C

5.1: sodium hydroxide / water / 1.5 h / 100 °C

5.2: 0 °C / pH 1 - 2

6.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 25 °C

6.2: 23 h / 80 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; ammonia; hydrogen; ammonium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; copper(II) sulfide; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 96-73-1
2-chloro-5-nitro-benzenesulfonic acid

: 1033766-07-2
(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Heating / reflux

2.1: ammonia / tetrahydrofuran; water; toluene / 2 h / -10 °C

2.2: pH 4

3.1: ammonia; ammonium carbonate / copper(II) sulfide / water / 4 h / 120 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 26 h / 25 °C / 760.05 Torr

5.1: pyridine / acetonitrile / 16 h / 25 °C

6.1: diethyl ether; N,N-dimethyl acetamide / 1 h / 25 °C

7.1: sodium hydroxide / water / 1.5 h / 100 °C

7.2: 0 °C / pH 1 - 2

8.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 25 °C

8.2: 23 h / 80 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; thionyl chloride; ammonia; hydrogen; ammonium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; copper(II) sulfide; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene; acetonitrile;