3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

Base Information

Chemical Name:3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene
CAS No.:113748-85-9
Molecular Formula:C₃₂H₂₂ClF₇O₂
Molecular Weight:606.967
Hs Code.:

Synonyms:3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

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Chemical Property of 3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

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Technology Process of 3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

There total 6 articles about 3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 107-06-2,52399-93-6
1,2-dichloro-ethane

: 113748-84-8
6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

: 113748-85-9
3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; for 1h; Heating;
DOI:10.1021/jm00402a005

Reference yield:

: 28557-00-8
phenylzinc chloride

: 113748-85-9
3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

2: 83 percent / HBr / acetic acid / 5 h / Heating

3: 83 percent / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-), aq. NaOH / 1 h / Heating

With sodium hydroxide; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; cyclohexane; acetic acid;
DOI:10.1021/jm00402a005

Reference yield:

: 113748-80-4
3-methoxy-6,7-dihydro-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-85-9
3-(2-chloroethoxy)-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 3 h

2: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

3: 83 percent / HBr / acetic acid / 5 h / Heating

4: 83 percent / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-), aq. NaOH / 1 h / Heating

With sodium hydroxide; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; pyridinium hydrobromide perbromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; acetic acid;
DOI:10.1021/jm00402a005