4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

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Chemical Name:4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide
CAS No.:1429241-32-6
Molecular Formula:C₂₉H₂₂BrCl₂F₃N₄OS
Molecular Weight:682.391
Hs Code.:

Synonyms:4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

There total 8 articles about 4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1429242-14-7
1-(2,4-dichlorophenyl)-5-(5-(2-(4-(trifluoromethyl)phenyl)-ethynyl)thiophene-2-yl)-4-(hydroxymethyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

: 1429241-32-6
4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm401158e

Reference yield:

: 1160842-73-8
ethyl 4-(bromomethyl)-5-(5-bromothiophene-2-yl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

: 1429241-32-6
4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver nitrate; water / acetone / 60 °C

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; water / 0.17 h / Inert atmosphere

3.2: 12 h / 80 °C / Inert atmosphere

4.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; phosphorus tribromide; silver nitrate; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; acetone;

Reference yield:

: 1013649-25-6
5-(5-bromothiophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1429241-32-6
4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

2.1: silver nitrate; water / acetone / 60 °C

3.1: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; water / 0.17 h / Inert atmosphere

4.2: 12 h / 80 °C / Inert atmosphere

5.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); water; phosphorus tribromide; silver nitrate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; 1,2-dichloro-ethane; acetone;