3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine

Base Information

• Chemical Name: 3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine
• CAS No.: 198023-30-2
• Molecular Formula: C₂₁H₂₃N₅O₃
• Molecular Weight: 393.445
• Mol file: 198023-30-2.mol

Synonyms:3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine

Chemical Property of 3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine

There total 2 articles about 3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-Benzyl-1-benzyloxy-6-imino-9-methyl-1,6,7,9-tetrahydro-purin-8-one; compound with perchloric acid → 3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine (198023-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol / 2 h / 40 °C

2: 1.) K₂CO₃ / 1.) DMF, RT, 1 h, 2.) DMF, RT, 20 min

With sodium hydroxide; potassium carbonate; In ethanol;

DOI:10.1248/cpb.45.1601

Reference yield:

3-Benzyl-N-benzyloxy-5-formylamino-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine (198023-29-9) + methyl iodide (74-88-4) → 3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine (198023-30-2)

Guidance literature:

With potassium carbonate; Yield given. Multistep reaction; 1.) DMF, RT, 1 h, 2.) DMF, RT, 20 min;

DOI:10.1248/cpb.45.1601

Reference yield: 88.0%

3-Benzyl-N-benzyloxy-5-(formyl-methyl-amino)-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine (198023-30-2) → 7-Benzyl-3,9-dimethyl-7,9-dihydro-3H-purine-6,8-dione 6-(O-benzyl-oxime); hydrochloride

Guidance literature:

With hydrogenchloride; In ethanol; for 16h; Ambient temperature;

DOI:10.1248/cpb.45.1601

upstream raw materials:

3-Benzyl-N-benzyloxy-5-formylamino-1-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamidine

methyl iodide