{5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol

Base Information

Chemical Name:{5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol
CAS No.:1292850-26-0
Molecular Formula:C₁₈H₂₀Cl₂FNO
Molecular Weight:356.267
Hs Code.:

Synonyms:{5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol

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Chemical Property of {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol

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Technology Process of {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol

There total 6 articles about {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1292850-25-9
N-{4-chloro-2-[(2-chloro-5-fluorophenyl)(hydroxy)-methyl]phenyl}-2,2-dimethylpropanamide

: 1292850-26-0
{5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol

Guidance literature:: N-{4-chloro-2-[(2-chloro-5-fluorophenyl)(hydroxy)-methyl]phenyl}-2,2-dimethylpropanamide; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 2h;

With rochelle salt; In tetrahydrofuran; toluene; for 0.0833333h; Saturated solution;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 261762-59-8
(2-chloro-5-fluorophenyl)methanol

: 1292850-26-0
{5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - -40 °C

1.2: -40 - 20 °C

2.1: sec.-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C

2.2: 0.5 h / 0 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C

3.2: 0.08 h / Saturated solution

With oxalyl dichloride; sec.-butyllithium; dimethyl sulfoxide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 2252-50-8
2-chloro-5-fluoro-benzoic acid

: 1292850-26-0
{5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 0 °C / Reflux

1.2: Cooling with ice

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - -40 °C

2.2: -40 - 20 °C

3.1: sec.-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C

3.2: 0.5 h / 0 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C

4.2: 0.08 h / Saturated solution

With borane-THF; oxalyl dichloride; sec.-butyllithium; dimethyl sulfoxide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.01.065