261762-59-8

Basic information

• Product Name: 2-CHLORO-5-FLUOROBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 1381;2-CHLORO-5-FLUOROBENZYL ALCOHOL;(2-Chloro-5-fluorophenyl)methanol
• CAS NO: 261762-59-8
• Molecular Formula: C₇H₆ClFO
• Molecular Weight: 160.57
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 261762-59-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 68-72°C
• Boiling Point: 229.6°Cat760mmHg
• Flash Point: 92.7°C
• Appearance: /
• Density: 1.344g/cm³
• Vapor Pressure: 0.0387mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLORO-5-FLUOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-FLUOROBENZYL ALCOHOL(261762-59-8)
• EPA Substance Registry System: 2-CHLORO-5-FLUOROBENZYL ALCOHOL(261762-59-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 261762-59-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-fluorobenzyl alcohol is a chemical compound that belongs to the class of benzyl alcohols, which are commonly used in the synthesis of pharmaceuticals and agrochemicals. This specific compound has a chlorine atom at position 2 and a fluorine atom at position 5 on the benzene ring, giving it both chloro and fluoro substituents. It is commonly used as a building block in organic synthesis and as a reagent in chemical reactions to introduce the benzyl alcohol functional group onto other molecules. Its properties and reactivity make it a valuable tool in the development of new compounds for various applications in the chemical and pharmaceutical industries.

InChI:InChI=1/C7H6ClFO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4H2

Upstream product

• 84194-30-9 2-chloro-5-fluorobenzaldehyde 
• 647020-63-1 methyl 2-chloro-5-fluorobenzoate 
• 2252-50-8 2-chloro-5-fluoro-benzoic acid 

Downstream Products

• 1292850-25-9 N-{4-chloro-2-[(2-chloro-5-fluorophenyl)(hydroxy)-methyl]phenyl}-2,2-dimethylpropanamide 
• 1292850-26-0 {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chloro-5-fluorophenyl)methanol 
• 84194-30-9 2-chloro-5-fluorobenzaldehyde 
• 81778-09-8 1-(bromomethyl)-2-chloro-5-fluorobenzene 
• 1312954-59-8 1-chloro-4-fluoro-2-(isothiocyanatomethyl)benzene 
• 1312954-60-1 N-(2-chloro-5-fluorobenzyl)hydrazinecarbothioamide 
• 1312954-65-6 (R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one 
• 1312954-62-3 4-(2-chloro-5-fluorobenzyl)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one 
• 1312954-63-4 4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one 
• 1312954-64-5 (R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate 
• 1312954-61-2 methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate 
• 1231251-51-6 5-(2-chloro-5-fluoro-benzyloxy)-3-{4-(4-methyl-piperazin-1-yl)-2-[(tetrahydro-pyran-4-yl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-indazole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Methanol as hydrogen source: Transfer hydrogenation of aromatic aldehydes with a rhodacycle

A cyclometalated rhodium complex has been shown to perform highly selective and efficient reduction of aldehydes, deriving the hydrogen from methanol. With methanol as both the solvent and hydrogen donor under mild conditions and an open atmosphere, a wide range of aromatic aldehydes were reduced to the corresponding alcohols, without affecting other functional groups.

CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS

Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.