2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

Base Information

Chemical Name:2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime
CAS No.:1134395-14-4
Molecular Formula:C₁₉H₁₈F₃NO₅S
Molecular Weight:429.417
Hs Code.:

Synonyms:2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

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Chemical Property of 2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

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Technology Process of 2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

There total 5 articles about 2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1134395-13-3
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

: 1134395-14-4
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

Guidance literature:: With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.3390/molecules26020477

Reference yield: 85.0%

: 1134395-13-3
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

: 98-59-9
p-toluenesulfonyl chloride

: 1134395-14-4
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 4 - 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2008.12.008

Reference yield:

: 4360-68-3
2-(4-bromophenyl)-2-methyl-1,3-dioxolane

: 1134395-14-4
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

1.2: 3 h / -78 - -60 °C

2.1: hydroxylamine hydrochloride; sodium ethanolate / ethanol / 18 h / 78 °C

3.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 18 h / 20 °C

With dmap; n-butyllithium; hydroxylamine hydrochloride; sodium ethanolate; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.3390/molecules26020477