2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

Base Information

Chemical Name:2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime
CAS No.:1134395-13-3
Molecular Formula:C₁₂H₁₂F₃NO₃
Molecular Weight:275.227
Hs Code.:

Synonyms:2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

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Technology Process of 2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

There total 2 articles about 2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one

: 1134395-13-3
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In ethanol; at 60 ℃; for 14h;
DOI:10.1016/j.bmcl.2008.12.008

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1134395-13-3
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: p-toluenesulfonyl chloride / toluene / 24 h / 110 °C / Dean-Stark

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

2.2: 3 h / -78 - -60 °C

3.1: hydroxylamine hydrochloride; sodium ethanolate / ethanol / 18 h / 78 °C

With n-butyllithium; hydroxylamine hydrochloride; sodium ethanolate; p-toluenesulfonyl chloride; In tetrahydrofuran; ethanol; toluene;
DOI:10.3390/molecules26020477

Reference yield: 100.0%

: 1134395-13-3
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one oxime

: 1134395-14-4
2,2,2-trifluoro-1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethan-1-one O-tosyl oxime

Guidance literature:: With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.3390/molecules26020477