Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine

Base Information

• Chemical Name: Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine
• CAS No.: 85372-11-8
• Molecular Formula: C₆H₁₅N*C₄₄H₅₀N₅O₁₁PSi
• Molecular Weight: 985.159

Synonyms:Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine

Chemical Property of Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine

Chemical Property:

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Technology Process of Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine

There total 6 articles about Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4-methoxytrityl)inosine (69659-63-8) → Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine (85372-11-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / imidazole / pyridine

2: 1.) pyridine

3: oximate

With 1H-imidazole; oximate; In pyridine;

DOI:10.1016/S0040-4039(00)85714-7

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine (85372-11-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / imidazole / pyridine

2: 1.) pyridine

3: oximate

With 1H-imidazole; oximate; In pyridine;

DOI:10.1016/S0040-4039(00)85714-7

Reference yield:

Inosine (58-63-9) → Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester; compound with triethyl-amine (85372-11-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent

2: 40 percent / imidazole / pyridine

3: 1.) pyridine

4: oximate

With 1H-imidazole; oximate; In pyridine;

DOI:10.1016/S0040-4039(00)85714-7

upstream raw materials:

Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

2-(4-nitrophenyl)ethanol

5'-O-(4-methoxytrityl)inosine

9-{(2R,3R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Downstream raw materials:

C₆₆H₈₈N₉O₁₅PSi₃

C₆₈H₆₈N₉O₁₇PSi

C₇₄H₈₄Cl₂N₁₀O₂₀P₂Si₂

C₉₀H₁₂₀N₁₄O₂₄P₂Si₄

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