Technology Process of tert-butyl (3S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate
There total 5 articles about tert-butyl (3S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
at 0 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: diethyl ether / 0.5 h / 0 °C
2: hydrogen bromide / tetrahydrofuran; water / 1 h / 0 °C
3: potassium fluoride / N,N-dimethyl-formamide / 1 h / 20 °C
4: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C
With
potassium fluoride; sodium tetrahydroborate; hydrogen bromide;
In
tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
3: modified Finkel-stein reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen bromide / tetrahydrofuran; water / 1 h / 0 °C
2: potassium fluoride / N,N-dimethyl-formamide / 1 h / 20 °C
3: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C
With
potassium fluoride; sodium tetrahydroborate; hydrogen bromide;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
2: modified Finkel-stein reaction;