methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate

Base Information

• Chemical Name: methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate
• CAS No.: 120427-74-9
• Molecular Formula: C₂₈H₃₈O₅S
• Molecular Weight: 486.673

Synonyms:methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate

Chemical Property of methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate

Chemical Property:

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MSDS Files:

SDS file from LookChem

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Technology Process of methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate

There total 5 articles about methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 3-mercaptopropionate (2935-90-2) + (2R,3S)-(+) methyl 2,3-epoxy-3-<2-(8-phenyloctyl)phenyl>propionate (145987-15-1) → methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate (120427-74-9)

Guidance literature:

With triethylamine; In methanol;

Reference yield:

2-(8-phenyloctyl) benzaldehyde (96964-45-3) → methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate (120427-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / diethyl ether / 2.5 h / 0 °C

2: Et₃N / methanol / 18 h / Ambient temperature

With sodium methylate; triethylamine; In methanol; diethyl ether;

DOI:10.1021/jm00389a001

Reference yield:

Methyl 3-mercaptopropionate (2935-90-2) + ((+/-)-trans)-Methyl 3-<2-(8-phenyloctyl)phenyl>oxiranecarboxylate (108082-09-3,120379-10-4,120427-72-7,145987-15-1) → 3-Hydroxy-2-(2-methoxycarbonyl-ethylsulfanyl)-3-[2-(8-phenyl-octyl)-phenyl]-propionic acid methyl ester (108082-11-7) + methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate (120427-74-9)

Guidance literature:

With triethylamine; In methanol; for 18h; Ambient temperature;

DOI:10.1021/jm00389a001

upstream raw materials:

Methyl 3-mercaptopropionate

((+/-)-trans)-Methyl 3-<2-(8-phenyloctyl)phenyl>oxiranecarboxylate

2-(8-phenyloctyl) benzaldehyde

diazomethane

Downstream raw materials:

2(S)-hydroxy-3(R)-(2-carboxyethylthio)-3-[2(8-phenyloctyl)phenyl]-propanoic acid

(2R,3S)-3-(2-Carboxy-ethylsulfanyl)-2-hydroxy-3-[2-(8-phenyl-octyl)-phenyl]-propionic acid

pobilukast

Methyl 2-t-butyldiphenylsilyloxy-3-[(2-carbomethoxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoate

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