C₁₆H₁₀F₆S₂

Base Information

• Chemical Name: C₁₆H₁₀F₆S₂
• CAS No.: 889110-18-3
• Molecular Formula: C₁₆H₁₀F₆S₂
• Molecular Weight: 380.378
• Mol file: 889110-18-3.mol

Synonyms:C₁₆H₁₀F₆S₂

Chemical Property of C₁₆H₁₀F₆S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₆H₁₀F₆S₂

There total 3 articles about C₁₆H₁₀F₆S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2,2,3,3,4,4,4-heptafluorobutanal (375-02-0) + thiophenol (108-98-5) → C16H10F6S2 (889110-18-3)

Guidance literature:

2,2,3,3,4,4,4-heptafluorobutanal; thiophenol; With titanium tetrachloride; In dichloromethane;

With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane;

DOI:10.1055/s-2006-926352

Reference yield:

2,2,3,3,4,4,4-heptafluoro-butane-1,1-diol (375-21-3) + thiophenol (108-98-5) → C16H10F6S2 (889110-18-3)

Guidance literature:

2,2,3,3,4,4,4-heptafluoro-butane-1,1-diol; thiophenol; With titanium tetrachloride; In dichloromethane; at 20 ℃;

With tetrabutylammomium bromide; potassium hydroxide; In dichloromethane; water; at 20 ℃;

DOI:10.1016/j.bmcl.2013.08.108

Reference yield:

C16H11F7S2 → C16H10F6S2 (889110-18-3)

Guidance literature:

With tetrabutylammomium bromide; potassium hydroxide; In dichloromethane; water;

DOI:10.1021/jm301076q

upstream raw materials:

2,2,3,3,4,4,4-heptafluorobutanal

thiophenol

2,2,3,3,4,4,4-heptafluoro-butane-1,1-diol

Downstream raw materials:

3,3,4,4,4-pentafluoro-2-(2-oxo-2-phenyl-ethyl)-thiobutyric acid S-phenyl ester

3-methyl-4-oxo-2-pentafluoroethyl-hexanethioic acid S-phenyl ester

5-(Bis-phenylsulfanyl-methylene)-6,6,7,7,7-pentafluoro-4-methyl-heptan-3-one

4-(Bis-phenylsulfanyl-methylene)-5,5,6,6,6-pentafluoro-hexan-2-one

Refernces

• 1、 Kanishchev, Oleksandr S.,Lavoignat, Adeline,Picot, Stéphane,Médebielle, Maurice,Bouillon, Jean-Philippe. "New route to the 5-((arylthio- and heteroarylthio)methylene)-3-(2,2,2- trifluoroethyl)-furan-2(5H)-ones - Key intermediates in the synthesis of 4-aminoquinoline γ-lactams as potent antimalarial compounds". . p. 6167 - 6171. Retrieved 2013/11/06.