4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester

Base Information

• Chemical Name: 4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester
• CAS No.: 159116-91-3
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Mol file: 159116-91-3.mol

Synonyms:4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester

Chemical Property of 4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester

There total 2 articles about 4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 4-oxo-butanoate (51534-77-1) + (R)-2-methoxy-1-phenylethylamine (64715-85-1,91298-74-7,127180-88-5) → 4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester (159116-91-3)

Guidance literature:

With sodium sulfate; In benzene; for 1.5h; Ambient temperature;

DOI:10.1021/ja00149a011

Reference yield:

(R)-phenylglycine (875-74-1) → 4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester (159116-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KH / 1.) THF, overnight, 2.) THF, 3 h

2: 92 percent / Na₂SO₄ / benzene / 1.5 h / Ambient temperature

With potassium hydride; sodium sulfate; In benzene;

DOI:10.1021/ja00149a011

Reference yield: 37.0%

diethyl phosphite lithium salt (72726-66-0) + 4-[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-butyric acid tert-butyl ester (159116-91-3) → (R)-4-(Diethoxy-phosphoryl)-4-((R)-2-methoxy-1-phenyl-ethylamino)-butyric acid tert-butyl ester (159117-14-3)

Guidance literature:

In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1021/ja00099a084

upstream raw materials:

tert-butyl 4-oxo-butanoate

(R)-2-methoxy-1-phenylethylamine

(R)-phenylglycine

Downstream raw materials:

(R)-4-(Diethoxy-phosphoryl)-4-((R)-2-methoxy-1-phenyl-ethylamino)-butyric acid tert-butyl ester