(R)-(-)-1-Amino-1-phenyl-2-methoxyethane

Base Information

• Chemical Name: (R)-(-)-1-Amino-1-phenyl-2-methoxyethane
• CAS No.: 64715-85-1
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Hs Code.: 2922190090
• European Community (EC) Number: 631-184-6
• DSSTox Substance ID: DTXSID40452029
• Nikkaji Number: J721.480D
• Wikidata: Q76416455
• Mol file: 64715-85-1.mol

Synonyms:64715-85-1;(R)-(-)-1-Amino-1-phenyl-2-methoxyethane;(R)-2-Methoxy-1-phenylethanamine;(1R)-2-METHOXY-1-PHENYLETHANAMINE;(R)-(-)-2-Methoxy-1-phenylethylamine;(1R)-2-Methoxy-1-phenylethan-1-amine;(R)-2-methoxy-1-phenylethan-1-amine;SCHEMBL791984;DTXSID40452029;CMTDMIYJXVBUDX-VIFPVBQESA-N;(R)-1-Phenyl-2-methoxyethanamine;MFCD01862274;AKOS006344923;AS-64802;CS-0434170;EN300-316975;N12470;(R)-(-)-2-Methoxy-1-phenylethylamine, >=95.0% (HPLC)

Chemical Property of (R)-(-)-1-Amino-1-phenyl-2-methoxyethane

Chemical Property:

• Vapor Pressure: 0.0667mmHg at 25°C
• Refractive Index: 1.523
• Boiling Point: 230.2°C at 760 mmHg
• PKA: 8.90±0.10(Predicted)
• Flash Point: 79.6°C
• PSA: 35.25000
• Density: 1.011g/cm³
• LogP: 2.03310
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 99.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(-)-1-Amino-1-phenyl-2-methoxyethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/38-43-52
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(C1=CC=CC=C1)N
• Isomeric SMILES: COC[C@@H](C1=CC=CC=C1)N

Technology Process of (R)-(-)-1-Amino-1-phenyl-2-methoxyethane

There total 8 articles about (R)-(-)-1-Amino-1-phenyl-2-methoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

D-2-phenylglycinol (56613-80-0) + methyl iodide (74-88-4) → (R)-2-methoxy-1-phenylethylamine (64715-85-1,91298-74-7,127180-88-5)

Guidance literature:

D-2-phenylglycinol; With potassium hydride; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 25 ℃; for 5h; Inert atmosphere;

DOI:10.15227/orgsyn.075.0019

Reference yield: 85.0%

(R)-N-benzylidene-2-hydroxy-1-phenylethylamine (74879-43-9,92850-36-7,142292-44-2,139437-46-0) → (R)-2-methoxy-1-phenylethylamine (64715-85-1,91298-74-7,127180-88-5)

Guidance literature:

(R)-N-benzylidene-2-hydroxy-1-phenylethylamine; MeHal; With sodium hydride; In tetrahydrofuran; at 20 - 40 ℃; for 2.25h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h;

DOI:10.1016/S0957-4166(02)00587-6

Reference yield:

N,N-diallyl-N-[(1R)-2-methoxy-1-phenylethyl]amine (860304-24-1) → (R)-2-methoxy-1-phenylethylamine (64715-85-1,91298-74-7,127180-88-5)

Guidance literature:

With Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 12h;

DOI:10.1021/jm0409019

upstream raw materials:

D-2-phenylglycinol

methyl iodide

(R)-phenylglycine

(R)-N-benzylidene-2-hydroxy-1-phenylethylamine

Downstream raw materials:

((R)-2-Methoxy-1-phenyl-ethyl)-[3-phenyl-prop-(E)-ylidene]-amine

R(-)-N-(1-phenyl-2-methoxyethyl)-N-trimethylsilylmethylamine

(S)-((R)-2-Methoxy-1-phenyl-ethylamino)-p-tolyl-acetonitrile

(R)-benzylidene-(2-methoxy-1-phenylethyl)amine