(E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate

Base Information

• Chemical Name: (E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate
• CAS No.: 361447-40-7
• Molecular Formula: C₁₅H₁₈O₂
• Molecular Weight: 230.307
• Mol file: 361447-40-7.mol

Synonyms:(E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate

Chemical Property of (E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate

There total 2 articles about (E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1,4-dibromo-butane (110-52-1) + (E)-methyl 4-phenylbut-3-enoate (91083-82-8,24891-74-5,34541-74-7) → (E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate (361447-40-7)

Guidance literature:

(E)-methyl 4-phenylbut-3-enoate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

1,4-dibromo-butane; In tetrahydrofuran; hexane; at 20 ℃; for 18h;

DOI:10.1055/s-2001-15059

Reference yield:

trans-styrylacetic acid (2243-53-0,59744-46-6,1914-58-5) → (E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate (361447-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / H₂SO₄ / CH₂Cl₂ / 24 h / Heating

2.1: LDA / hexane; tetrahydrofuran / 0.17 h / -78 °C

2.2: 40 percent / hexane; tetrahydrofuran / 18 h / 20 °C

With sulfuric acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1055/s-2001-15059

Reference yield: 73.0%

(E)-Methyl 1-(2-phenylvinyl)-1-cyclopentanecarboxylate (361447-40-7) → (E)-1-Hydroxymethyl-1-(2-phenylvinyl)cyclopentane (361447-41-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1055/s-2001-15059

upstream raw materials:

1,4-dibromo-butane

(E)-methyl 4-phenylbut-3-enoate

trans-styrylacetic acid

Downstream raw materials:

(E)-1-Hydroxymethyl-1-(2-phenylvinyl)cyclopentane

(E)-1-(2-Phenylvinyl)-1-cyclopentanecarbaldehyde

Refernces