N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

Base Information

Chemical Name:N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide
CAS No.:762297-97-2
Molecular Formula:C₁₀H₁₀BrF₂NO
Molecular Weight:278.096
Hs Code.:
DSSTox Substance ID:DTXSID101227820

Synonyms:N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide;762297-97-2;SCHEMBL4770832;ZXOIAPABULLMOI-UHFFFAOYSA-N;DTXSID101227820

Suppliers and Price of N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:276.99138
Heavy Atom Count:15
Complexity:238

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C(=O)NC1=CC(=C(C=C1F)F)Br

Technology Process of N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

There total 3 articles about N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 452-92-6
(5-bromo-2,4-difluorophenyl)amine

: 79-30-1
isobutyryl chloride

: 762297-97-2
N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm060381c

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 762297-97-2
N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / HNO₃; H₂SO₄ / 1 h / 0 °C

2: 59 percent / aq. NH₄Cl; Fe / ethanol; tetrahydrofuran / 2 h / Heating

3: 94 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

With sulfuric acid; nitric acid; iron; ammonium chloride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm060381c

Reference yield:

: 345-24-4
5-bromo-2,4-difluoronitrobenzene

: 762297-97-2
N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / aq. NH₄Cl; Fe / ethanol; tetrahydrofuran / 2 h / Heating

2: 94 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

With iron; ammonium chloride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm060381c