tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate
CAS No.:762298-05-5
Molecular Formula:C₂₀H₂₈F₂N₂O₃
Molecular Weight:382.451
Hs Code.:

Synonyms:tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

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Chemical Property of tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

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Technology Process of tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

There total 5 articles about tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 762298-01-1
tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

: 762298-05-5
tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; at 20 ℃; under 10343.2 Torr;
DOI:10.1021/jm060381c

Reference yield:

: 762297-97-2
N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

: 762298-05-5
tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

2: 85 percent / H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

With hydrogen; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm060381c

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 762298-05-5
tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / HNO₃; H₂SO₄ / 1 h / 0 °C

2: 59 percent / aq. NH₄Cl; Fe / ethanol; tetrahydrofuran / 2 h / Heating

3: 94 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

4: 59 percent / K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

5: 85 percent / H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

With sulfuric acid; hydrogen; nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; 4: Suzuki coupling;
DOI:10.1021/jm060381c