(3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Base Information

Chemical Name:(3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole
CAS No.:1301708-04-2
Molecular Formula:C₃₂H₃₁N₂P
Molecular Weight:474.585
Hs Code.:

Synonyms:(3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

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Chemical Property of (3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

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Technology Process of (3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

There total 7 articles about (3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: (3aR,7aR)-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

: 100-39-0
benzyl bromide

: 1301708-04-2
(3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Guidance literature:: (3aR,7aR)-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 ℃; for 19h; Inert atmosphere;
DOI:10.1002/chem.201003314

Reference yield: 61.0%

: 1354693-91-6
C₂₀H₂₁FN₂

: 15475-27-1,4346-39-8
potassium diphenylphosphine

: 1301708-04-2
(3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Guidance literature:: In tetrahydrofuran; Inert atmosphere;
DOI:10.1002/adsc.201100684

Reference yield:

: 503111-21-5
(3aR,7aR)-2-(2'-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

: 1301708-04-2
(3aR,7aR)-1-benzyl-2-(2'-(diphenylphosphanyl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 19 h / 20 °C / Inert atmosphere

With potassium hydride; In tetrahydrofuran;
DOI:10.1002/chem.201003314