4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid

Base Information

Chemical Name:4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid
CAS No.:1215215-95-4
Molecular Formula:C₁₈H₁₁Br₂F₄NO₃
Molecular Weight:525.092
Hs Code.:

Synonyms:4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid

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Chemical Property of 4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid

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Technology Process of 4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid

There total 4 articles about 4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215215-94-3
methyl 4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoate

: 1215215-95-4
4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid

Guidance literature:: With water; potassium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;

Reference yield:

: 1132701-15-5
1-(3,5-dibromo-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

: 1215215-95-4
4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C

1.2: 18 h / 20 °C / Cooling with ice

2.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 80 °C

2.2: 18 h / 0 - 20 °C

3.1: water; potassium hydroxide / tetrahydrofuran; ethanol / 2 h / 20 °C

With N-chloro-succinimide; potassium tert-butylate; water; potassium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol;

Reference yield:

: 1350352-17-8
1,3-dibromo-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1215215-95-4
4-[5-(3,5-dibromo-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 80 °C

1.2: 18 h / 0 - 20 °C

2.1: water; potassium hydroxide / tetrahydrofuran; ethanol / 2 h / 20 °C

With N-chloro-succinimide; water; potassium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol;