N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

Base Information

Chemical Name:N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide
CAS No.:400802-60-0
Molecular Formula:C₂₈H₃₄ClF₃N₆O₅S₂
Molecular Weight:691.195
Hs Code.:

N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

Synonyms:N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

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Chemical Property of N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

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Technology Process of N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

There total 6 articles about N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 400798-00-7
5-methanesulfonyl-1-oxiranylmethyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 400803-12-5
4-(2-chloro-6-methanesulfonylamino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 400802-60-0
N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

Guidance literature:: With aqueous KOH; trifluoroacetic acid; In ethanol; dichloromethane;

Reference yield:

: 400803-05-6
4-(2-chloro-6-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 400802-60-0
N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate / Pd-C / methanol

2: sodium hydrogencarbonate; triethylamine / dichloromethane; ethyl acetate

3: aqueous KOH; trifluoroacetic acid / ethanol; dichloromethane

With aqueous KOH; ammonium formate; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; Pd-C; In methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 3209-22-1
1,2-Dichloro-3-nitrobenzene

: 400802-60-0
N-[3-chloro-2-(4-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperazin-1-yl)-phenyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile

2: ammonium formate / Pd-C / methanol

3: sodium hydrogencarbonate; triethylamine / dichloromethane; ethyl acetate

4: aqueous KOH; trifluoroacetic acid / ethanol; dichloromethane

With aqueous KOH; ammonium formate; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; Pd-C; In methanol; ethanol; dichloromethane; ethyl acetate; acetonitrile;