1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol

Base Information

Chemical Name:1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol
CAS No.:1562194-60-8
Molecular Formula:C₁₆H₂₁ClO₃
Molecular Weight:296.794
Hs Code.:

Synonyms:1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol

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Chemical Property of 1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol

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Technology Process of 1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol

There total 4 articles about 1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1191-95-3
cyclobutanone

: 1562194-55-1
2-((2-bromo-6-chlorobenzyl)oxy)tetrahydro-2H-pyrane

: 1562194-60-8
1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol

Guidance literature:: 2-((2-bromo-6-chlorobenzyl)oxy)tetrahydro-2H-pyrane; With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 0.5h;

cyclobutanone; In tetrahydrofuran; at -70 ℃; for 1h;

Reference yield:

: 108-37-2
1-bromo-3-chlorobenzene

: 1562194-60-8
1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 °C

1.2: 1 h

2.1: potassium borohydride / ethanol / 2 h / 0 °C

3.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 5 °C

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C

4.2: 1 h / -70 °C

With n-butyllithium; potassium borohydride; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

Reference yield:

: 64622-16-8
2-bromo-6-chlorobenzaldehyde

: 1562194-60-8
1-(3-chloro-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)cyclobutanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium borohydride / ethanol / 2 h / 0 °C

2.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 5 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C

3.2: 1 h / -70 °C

With n-butyllithium; potassium borohydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol;