N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid

Base Information

• Chemical Name: N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid
• CAS No.: 98653-71-5
• Molecular Formula: C₂₄H₃₁NO₅
• Molecular Weight: 413.514
• Mol file: 98653-71-5.mol

Synonyms:N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid

Chemical Property of N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid

There total 2 articles about N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + androst-4-en-3-one-17β-carboxylic acid (302-97-6) → N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid (98653-71-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00149a027

Reference yield: 55.0%

N-Bromosuccinimide (128-08-5) + androst-4-en-3-one-17β-carboxylic acid (302-97-6) → N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid (98653-71-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2010.03.085

Reference yield:

tyrosamine (51-67-2) + N-hydroxysuccinimide ester of 4-androsten-3-one-17β-carboxylic acid (98653-71-5) → (8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid [2-(4-hydroxy-phenyl)-ethyl]-amide

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; for 16h; Ambient temperature;

DOI:10.1021/jm00149a027

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

androst-4-en-3-one-17β-carboxylic acid

N-Bromosuccinimide