5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide
CAS No.:1331783-84-6
Molecular Formula:C₂₃H₁₇Cl₃F₃N₅O₃
Molecular Weight:574.774
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

There total 5 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1331784-06-5
4-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

: 1331783-84-6
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With silver nitrate; In water; acetone; for 2h; Reflux;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1265634-36-3
5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 1331783-84-6
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 5 h / Reflux

2: 1 h / Reflux

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 14 h / Reflux

4: silver nitrate / water; acetone / 2 h / Reflux

With N-Bromosuccinimide; hydroxylamine hydrochloride; potassium carbonate; silver nitrate; dibenzoyl peroxide; In tetrachloromethane; ethanol; water; acetone;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1332262-52-8
(Z)-N-(1-amino-1-(hydroxyimino)-2-methylpropan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 1331783-84-6
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1 h / Reflux

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 14 h / Reflux

3: silver nitrate / water; acetone / 2 h / Reflux

With N-Bromosuccinimide; silver nitrate; dibenzoyl peroxide; In tetrachloromethane; water; acetone;
DOI:10.1016/j.bmcl.2011.06.017