1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:180623-75-0
Molecular Formula:C₂₂H₂₂F₃IN₂O₄
Molecular Weight:562.327
Hs Code.:

Synonyms:1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108-24-7
acetic anhydride

: 180623-55-6
1-(4-amino-3-iodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 180623-75-0
1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In benzene; for 1h; Heating;
DOI:10.1021/jm960208o

Reference yield:

: 10268-26-5
1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-nitrophenyl)methyl]isoquinoline

: 180623-75-0
1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / tetrahydrofuran / Ambient temperature

2: 87 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr

3: 84 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / methanol; CH₂Cl₂

4: 94 percent / benzene / 1 h / Heating

With hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1021/jm960208o

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 180623-75-0
1-(4-Acetamido-3-iodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 58 percent / toluene / 72 h / Heating

2: POCl₃ / acetonitrile / 4 h / Heating

3: NaBH₄ / methanol / Ambient temperature

4: 50 percent / tetrahydrofuran / Ambient temperature

5: 87 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr

6: 84 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / methanol; CH₂Cl₂

7: 94 percent / benzene / 1 h / Heating

With sodium tetrahydroborate; hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; acetonitrile; benzene;
DOI:10.1021/jm960208o