(2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid

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Chemical Name:(2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid
CAS No.:234080-95-6
Molecular Formula:C₂₅H₃₀N₆O₄S
Molecular Weight:510.617
Hs Code.:

Synonyms:(2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid

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Chemical Property of (2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid

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Technology Process of (2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid

There total 8 articles about (2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 234080-93-4
(2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzylamino]-propionic acid

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 234080-95-6
(2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; at 20 ℃; for 0.5h; pH=3 - 4;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 234082-01-0
4-[4-(pyrimidin-2-yl)-piperazin-1-yl]-benzyl alcohol

: 234080-95-6
(2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 142 mg / MnO₂ / ethyl acetate / 2 h / 20 °C

2: 288 mg / sodium cyanoborohydride; acetic acid / methanol; CH₂Cl₂ / 0.5 h / 20 °C / pH 3 - 4

3: 224 mg / trifluoroacetic acid; anisole / CH₂Cl₂ / 16 h / 20 °C

4: 81 percent / sodium cyanoborohydride; acetic acid / methanol; CH₂Cl₂ / 0.5 h / 20 °C / pH 3 - 4

With manganese(IV) oxide; sodium cyanoborohydride; acetic acid; methoxybenzene; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 233283-14-2
ethyl 4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoate

: 234080-95-6
(2S)-benzenesulfonylamino-3-[methyl-[4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzyl]-amino]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutyl aluminum hydride / CH₂Cl₂; toluene / 1 h / -78 °C

2: 142 mg / MnO₂ / ethyl acetate / 2 h / 20 °C

3: 288 mg / sodium cyanoborohydride; acetic acid / methanol; CH₂Cl₂ / 0.5 h / 20 °C / pH 3 - 4

4: 224 mg / trifluoroacetic acid; anisole / CH₂Cl₂ / 16 h / 20 °C

5: 81 percent / sodium cyanoborohydride; acetic acid / methanol; CH₂Cl₂ / 0.5 h / 20 °C / pH 3 - 4

With manganese(IV) oxide; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; methoxybenzene; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2005.10.060