(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine

Base Information

Chemical Name:(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine
CAS No.:78342-45-7
Molecular Formula:C₁₈H₂₂N₂O₂
Molecular Weight:298.385
Hs Code.:

Synonyms:(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine

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Chemical Property of (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine

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Technology Process of (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine

There total 12 articles about (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 591-50-4
iodobenzene

: 78342-46-8
(2R,5S)-5-isopropyl-3,6-dimethoxy-2-propargyl-2,5-dihydropyrazine

: 78342-45-7
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃; for 24h;
DOI:10.3891/acta.chem.scand.51-0873

Reference yield: 45.0%

: 591-50-4
iodobenzene

: (2S,5R)-2-Isopropyl-3,6-dimethoxy-5-(3-tributylstannanyl-prop-2-ynyl)-2,5-dihydro-pyrazine

: 78342-45-7
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In 1,2-dichloro-ethane; for 2h; Heating;
DOI:10.3891/acta.chem.scand.51-0873

Reference yield: 30.0%

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 1794-48-5
1-bromo-3-phenylprop-2-yne

: 1186303-73-0
(2R,5S)-5-isopropyl-3,6-dimethoxy-2-(1-phenylpropa-1,2-dien-1-yl)-2,5-dihydropyrazine

: 78342-45-7
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(3-phenyl-2-propyn-1-yl)pyrazine

Guidance literature:: (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.166667h; Inert atmosphere;

With copper(I) bromide dimethylsulfide complex; dimethylsulfide; In tetrahydrofuran; hexane; at -30 ℃; for 0.5h; Inert atmosphere;

1-bromo-3-phenylprop-2-yne; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 17h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.200900462