tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate
CAS No.:280762-64-3
Molecular Formula:C₃₁H₃₉N₃O₉
Molecular Weight:597.665
Hs Code.:

tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

Synonyms:tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

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Chemical Property of tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

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Technology Process of tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

There total 1 articles about tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 280762-60-9
(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-2-pyrazinyl]methyl}-3-pyridinyl)ethenyl]-1,3-oxazolidin-2-one

: 280762-64-3
tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

Guidance literature:: (4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-2-pyrazinyl]methyl}-3-pyridinyl)ethenyl]-1,3-oxazolidin-2-one; With hydrogenchloride; In acetonitrile; at 20 ℃; for 0.75h;

di-tert-butyl dicarbonate; With dmap; triethylamine; In acetonitrile; at 20 ℃; for 52h;
DOI:10.1016/S0040-4020(00)00121-6

Reference yield:

: 280762-64-3
tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-tert-butoxycarbonylamino-4-[4-((S)-2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-5-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pyridin-3-yl]-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Li₂CO₃ / methanol / 17 h / 20 °C

1.2: 53 percent / aq. HCl; H₂ / Pd/C / methanol / 3 h / 20 °C / 1034.3 Torr

2.1: 68 percent / Et₃N / CH₂Cl₂ / 5 h / 0 °C

With lithium carbonate; triethylamine; In methanol; dichloromethane; 1.1: Hydrolysis / 1.2: Catalytic hydrogenation / 2.1: Esterification;
DOI:10.1016/S0040-4020(00)00121-6

Reference yield:

: 280762-64-3
tert-butyl-(4S)-4-[(E:Z)-2-(5-(benzyloxy)-4-{(2S)-2-[(tert-butoxycarbonyl)amio]-3-methoxy-3-oxopropyl}-3-pyridinyl)ethenyl]-2-oxo-1,3-oxazolidine-3-carboxylate

: 4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-3-(3-tert-butoxycarbonylamino-3-carboxy-propyl)-1-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-pentyl)-5-hydroxy-pyridinium; iodide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Li₂CO₃ / methanol / 17 h / 20 °C

1.2: 53 percent / aq. HCl; H₂ / Pd/C / methanol / 3 h / 20 °C / 1034.3 Torr

2.1: Jones reagent / acetone / 0.67 h / 20 °C

3.1: 0.030 g / methanol; benzene / 0.25 h / 20 °C

4.1: 27 percent / dioxane / 4 h / Heating

5.1: LiOH*H₂O / H₂O; tetrahydrofuran / 1 h / 20 °C

With lithium hydroxide; jones reagent; lithium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetone; benzene; 1.1: Hydrolysis / 1.2: Catalytic hydrogenation / 2.1: Oxidation / 3.1: Esterification / 4.1: Quaternization / 5.1: Hydrolysis;
DOI:10.1016/S0040-4020(00)00121-6