2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

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Chemical Name:2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid
CAS No.:168046-06-8
Molecular Formula:C₃₂H₂₇N₃O₅
Molecular Weight:533.583
Hs Code.:

Synonyms:2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

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Chemical Property of 2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

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Technology Process of 2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

There total 8 articles about 2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 168047-46-9
ethyl 2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetate

: 168046-06-8
2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 1h; Ambient temperature;
DOI:10.1248/cpb.47.501

Reference yield:

: 5755-07-7
2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

: 168046-06-8
2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) NaH / 1.) THF, 0 deg C, 5 min, 2.) THF, RT, overnight

3: 99 percent / Fe, AcOH / methanol / 1 h / Heating

4: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

5: 95 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature

With sodium hydroxide; iron; sodium hydride; acetic acid; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1248/cpb.47.501

Reference yield:

: 7148-03-0
o-tolylbenzoic acid

: 168046-06-8
2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2, DMF / CH₂Cl₂ / 0.5 h / 0 °C

2: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

3: 95 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane;
DOI:10.1248/cpb.47.501