ACETIC ACID 2-(5-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YLMETHOXY)-ETHYL ESTER

Base Information

• Chemical Name: ACETIC ACID 2-(5-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YLMETHOXY)-ETHYL ESTER
• CAS No.: 81777-43-7
• Molecular Formula: C9H11 Cl N2 O5
• Molecular Weight: 262.65
• Mol file: 81777-43-7.mol

Synonyms:ACETIC ACID 2-(5-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YLMETHOXY)-ETHYL ESTER

Chemical Property of ACETIC ACID 2-(5-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YLMETHOXY)-ETHYL ESTER

Chemical Property:

• PSA: 90.39000
• LogP: -0.27280

Purity/Quality:

99% ^*data from raw suppliers

ACETIC ACID-2-(5-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YLMETHOXY)-ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ACETIC ACID 2-(5-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YLMETHOXY)-ETHYL ESTER

There total 1 articles about ACETIC ACID 2-(5-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YLMETHOXY)-ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetoxyethoxymethyl bromide (81777-40-4) + 5-chloro-2,4-bis-O-trimethylsilyluracil (58990-53-7) → trimethylsilyl bromide (2857-97-8) + Acetic acid 2-(5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester (81777-43-7)

Guidance literature:

Yield given. Multistep reaction; 1.) acetonitrile, 0 degC, 2.) 0 degC to R_.T_. 2 h;

DOI:10.1139/v82-081

Reference yield: 98.0%

Acetic acid 2-(5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester (81777-43-7) → 1-<(2-hydroxyethoxy)methyl>-5-chlorouracil (81777-50-6)

Guidance literature:

With ammonia; In methanol; for 5h; Ambient temperature;

DOI:10.1139/v82-081

upstream raw materials:

2-acetoxyethoxymethyl bromide

5-chloro-2,4-bis-O-trimethylsilyluracil

Downstream raw materials:

1-<(2-hydroxyethoxy)methyl>-5-chlorouracil