5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

Base Information

Chemical Name:5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile
CAS No.:1258852-79-7
Molecular Formula:C₂₆H₂₉N₅O₄
Molecular Weight:475.547
Hs Code.:

Synonyms:5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

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Chemical Property of 5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

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Technology Process of 5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

There total 14 articles about 5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₇N₅O₆

: 1258852-79-7
5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258852-79-7
5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: pyridine / toluene / 15.33 h / 20 - 80 °C

3.1: hydrogenchloride / 1,4-dioxane / 5.5 h / 20 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 6 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-ethylmorpholine;; pyridine; hydrogenchloride; oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1165923-89-6
1,1-dimethylethyl 6-hydroxy-5-methyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1258852-79-7
5-[3-(2-D-allothreonyl-5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / -30 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 28.5 h / Reflux

4.1: pyridine / toluene / 15.33 h / 20 - 80 °C

5.1: hydrogenchloride / 1,4-dioxane / 5.5 h / 20 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 6 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-ethylmorpholine;; pyridine; hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;